1-(2-Hydroxyethyl)piperazine → HCID 22760361, compound

Participants

Reaction Steps

With stirring, heat (on a steam bath) a mixture of 13g of 4'-fluoro-4-(1-chloroethyl)[1,1']biphenyl and 20g of 1-(2-hydroxyethyl piperazine for twenty hours. Treat the reaction mixture with 200 ml of water, filter and wash the solid with water to yield 1-(2-hydroxyethyl)-4-[1-(4'-fluoro[1,1']biphenyl-4-yl)ethyl]piperazine: m.p. 120°-123°. Recrystallize the product from acetonitrile, m.p. of 122°-123°.

Provenance & Evidence