Hydrochloric Acid → 2-Chloro-4'-methyl-3'-sulfamoylacetophenone

HRID 1703885Notes

Reaction equation

HRID 1703885 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[CH:9]=[N+]=[N-])=[CH:4][C:3]=1[S:13](=[O:16])(=[O:15])[NH2:14].[ClH:17].C(O)(C)C>COCCOCCOC>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[CH2:9][Cl:17])=[CH:4][C:3]=1[S:13](=[O:16])(=[O:15])[NH2:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 540475354'-Methyl-3'-sulfamoyl-diazoacetophenone

Product 1

HCID 136287832-Chloro-4'-methyl-3'-sulfamoylacetophenone

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

10 g of 4'-methyl-3'-sulfamoyl-diazoacetophenone were reacted as prescribed in Example 66(b) in diethylene glycol dimethyl ether with 37% HCl and worked up. Colorless crystals, melting point: 166° C. (from isopropanol).

Sources & evidence

ORD record
ord-24bba5bebc2f4a6a809fa02fdd801380
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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