Hydrochloric Acid → HCID 22760437, compound

HRID 1703925Notes

Reaction equation

HRID 1703925 reaction equation
Br.[CH2:2]([N:4]1[C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([S:17](=[O:22])(=[O:21])[N:18]([CH3:20])[CH3:19])[CH:11]=2)([OH:9])[CH2:7][S:6][C:5]1=[N:23][CH2:24][CH3:25])[CH3:3].Cl>>[ClH:16].[CH2:2]([N:4]1[C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([S:17](=[O:21])(=[O:22])[N:18]([CH3:19])[CH3:20])[CH:11]=2)([OH:9])[CH2:7][S:6][C:5]1=[N:23][CH2:24][CH3:25])[CH3:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22760425HCID 22760425, compound

Product 1

HCID 22760437HCID 22760437, compound

Procedure

10 g of 3-ethyl-2-ethylimino-4-(4-chloro-3-dimethylsulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrobromide were reacted according to Example 2(c) and the yellow precipitate of 3-ethyl-2-ethylimino-4-(4-chloro-3-dimethylsulfamoylphenyl)-1,3-thiazolidine-4-ol was rapidly filtered off. The compound so obtained was treated according to Example 3(c) with ethanolic hydrochloric acid and the end product was precipitated by adding diisopropyl ether. The solvent was decanted, 200 ml of water were added to the amorphous residue and the aqueous solution was lyophilized. Colorless amorphous solid body, decomposition beginning at 134° C., γ C=N 1615 cm-1.

Workup

  1. filtrationthe yellow precipitate of 3-ethyl-2-ethylimino-4-(4-chloro-3-dimethylsulfamoylphenyl)-1,3-thiazolidine-4-ol was rapidly filtered off
  2. customThe compound so obtained
  3. additionwas treated
  4. customthe end product was precipitated
  5. additionby adding diisopropyl ether
  6. customThe solvent was decanted
  7. addition200 ml of water were added to the amorphous residue
  8. customat 134° C.

Sources & evidence

ORD record
ord-d13da70d80484563908649a854a5e9e7
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

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