Sodium Bicarbonate → HCID 22760410, compound

HRID 1703928Notes

Reaction equation

HRID 1703928 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[CH2:13][S:12][C:11]3=[N:14][CH2:15][CH2:16][N:10]23)=[CH:5][C:4]=1[S:18](=[O:23])(=[O:22])[N:19]([CH3:21])[CH3:20].C(=O)(O)[O-].[Na+]>O>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[CH2:13][S:12][C:11]3=[N:14][CH2:15][CH2:16][N:10]23)=[CH:5][C:4]=1[S:18](=[O:23])(=[O:22])[N:19]([CH3:20])[CH3:21]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22760458HCID 22760458, compound

Product 1

HCID 22760410HCID 22760410, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

7.3 g of 3-(4-chloro-3-dimethylsulfamoylphenyl)-3-hydroxy-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-hydrobromide were dissolved in 100 ml of water at 35°-40° C. After adding a solution of 6 g of sodium bicarbonate in 200 ml of water, the mixture was stirred for 15 minutes at room temperature and the end product was filtered off. Colorless crystals, melting point: 154° C. (decomposition).

Workup

  1. filtrationthe end product was filtered off

Sources & evidence

ORD record
ord-00e80ba38c0f4bfbb3cb1e13b511578b
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Reaction notes

Loading…