Sodium Hydroxide → Piromidic acid

HRID 1703951Notes

Reaction equation

HRID 1703951 reaction equation
C([O:3][C:4]([C:6]1[C:7](=[O:23])[C:8]2[CH:13]=[N:12][C:11]([N:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)=[N:10][C:9]=2[N:19]([CH2:21][CH3:22])[CH:20]=1)=[O:5])C.[OH-].[Na+].CCN1C2C(=NC=C(N3CCCC3)N=2)C(=O)C(C(O)=O)=C1>O>[N:14]1([C:11]2[N:12]=[CH:13][C:8]3[C:7](=[O:23])[C:6]([C:4]([OH:5])=[O:3])=[CH:20][N:19]([CH2:21][CH3:22])[C:9]=3[N:10]=2)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 118556Ethyl 8-ethyl-5-oxo-2-(pyrrolidin-1-yl)-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylateHCID 13052389HCID 13052389, compound

Product 1

HCID 4855Piromidic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Saponification of this ester (5.5 g) under reflux in an alkaline solution (NaOH: 0.8 g / water: 40 cm3) gives, after acidification, the corresponding acid (pyromidic acid, melting point 322° C), which is identical to the product described in the literature.

Workup

  1. customgives

Sources & evidence

ORD record
ord-c5adcf6e4a9941d98a5a6d24bc00ca79
Source dataset
uspto-grants-1978_11
Patent number
US04125720

Reaction notes

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