HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenol → 1-Chloro-4-(3-chloropropoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Chloro-4-(3-chloropropoxy)benzene | HCID 12685610 | 90% |
Reaction Steps
A mixture of 157 g of 3-bromo-1-chloropropane, 129 g of p-chlorophenol and 165 g of potassium carbonate in 1 liter of acetone is refluxed for 3 days. The mixture is cooled, filtered and the filtrate concentrated under reduced pressure. The residue is distilled to give 184 g of product as an oil, bp 107°-116° C. at 0.5mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04125732 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-44478036caa245dbb5760e9c3a7c950b |
| Source note | uspto-grants-1978_11 |