Triethylamine → HCID 21480157, compound

HRID 1704128Notes

Reaction equation

HRID 1704128 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH:7]([CH3:10])[CH2:8][OH:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[CH3:20][S:21]([O:9][CH2:8][CH:7]([O:6][C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH3:10])(=[O:23])=[O:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 132594172-(4-Chlorophenoxy)propan-1-ol

Product 1

HCID 21480157HCID 21480157, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 51.5 g of 2-(p-chlorophenoxy)-1-propanol and 57.5 ml of triethylamine in 680 ml of dichloromethane is chilled to -10° C. To the solution is added dropwise with stirring 25.8 ml of methanesulfonyl chloride in 20 ml of dichloromethane. The mixture is stirred for 1 hour at -7° C. to -10° C. and washed with ice cold water, saturated NaCl, saturated NaHCO3 and dried (MgSO4). The solvent is removed under reduced pressure to give 73 g of product as an oil.

Workup

  1. additionTo the solution is added dropwise
  2. washwashed with ice cold water, saturated NaCl, saturated NaHCO3
  3. dry with materialdried (MgSO4)
  4. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-09bdbec7c4dd4773956db7737d865236
Source dataset
uspto-grants-1978_11
Patent number
US04125732

Reaction notes

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