1-Chlorobutane-2,3-dione → HCID 22758949, compound

HRID 1704178Notes

Reaction equation

ClCC(=O)C(=O)C.C(N)=S.Br[CH:12]([C:14](=O)[C:15](=[O:18])[CH2:16][CH3:17])[CH3:13].[C:20]([NH2:23])(=[S:22])[CH3:21]>>[CH3:21][C:20]1[S:22][C:12]([CH3:13])=[C:14]([C:15](=[O:18])[CH2:16][CH3:17])[N:23]=1

Participants

Reactant 4

HCID 796801-Chlorobutane-2,3-dione

HCID 2723949Thioacetamide

HCID 3005587Methanethioamide

HCID 22758943HCID 22758943, compound

Product 1

HCID 22758949HCID 22758949, compound

Procedure

It will be appreciated that reaction of 1-chloro-2,3-butanedione with thioformamide will lead to 4-acetylthiazoles, similarly, reaction of 2-bromo-3,4hexanedione with thioacetamide will yield 2,5-dimethyl-4-propionylthiazole.

Sources & evidence

ORD record: ord-0326eb9d1c8243118be4d70cdd70e040
Source dataset: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE029843

Reaction notes

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