Phosphorus sulfide (P2S5) → HCID 22758948, compound

HRID 1704180Notes

Reaction equation

HRID 1704180 reaction equation
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].[CH3:15][O:16][C:17](=O)[C@H:18]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH:19][CH:20]=O>C(Cl)(Cl)Cl>[CH2:22]([C:18]1[N:19]=[CH:20][S:2][C:17]=1[O:16][CH3:15])[CH:23]([CH3:25])[CH3:24]

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 10965012HCID 10965012, compound

Product 1

HCID 22758948HCID 22758948, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A 500 ml flask equipped with heating mantle, condenser, and drying tube is charged with 27.25 g (0.125 mole) of phosphorus pentasulfide, 17.3 g (0.1 mole) of N-formylleucine methyl ester, and 250 ml of chloroform, and the contents are refluxed for 24 hours. The reaction mixture is thereupon cooled to room temperature, washed with 250 ml of 10% potassium hydroxide, and then washed with 250 ml of distilled water.

Workup

  1. customA 500 ml flask equipped
  2. temperaturewith heating mantle, condenser
  3. customdrying tube
  4. temperaturethe contents are refluxed for 24 hours
  5. washwashed with 250 ml of 10% potassium hydroxide
  6. washwashed with 250 ml of distilled water

Sources & evidence

ORD record
ord-bab491e4593a4440bac26870960809ee
Source dataset
uspto-grants-1978_11
Patent number
USRE029843

Reaction notes

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