反应详情

A stirred solution of 9 g. (0.028 mole) of 7-(4-chlorobenzoyl)-3-methylthioindolin-2-one in 180 ml. of tetrahydrofuran was treated over a two-hour period with 45 g. of a commercial Raney nickel water suspension. After the addition was complete the mixture was filtered. A drop of concentrated hydrochloric acid was added to the filtrate which removed some color and the resulting solution was then stripped under water pump vacuum to yield a cream color material. Recrystallization from toluene gave needles, (93% yield); the material sintered at 177° C. and melted at 186° C.

1. additionAfter the addition
2. filtrationwas filtered
3. additionA drop of concentrated hydrochloric acid was added to the filtrate which
4. customremoved some color
5. customto yield a cream color material
6. customRecrystallization from toluene
7. customgave needles, (93% yield)
8. customsintered at 177° C.