3-(Dimethylamino)propyl chloride hydrochloride → Dimaprit hydrochloride

HRID 1704376Notes

Reaction equation

HRID 1704376 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[ClH:5].[CH3:6][N:7]([CH3:12])[CH2:8][CH2:9][CH2:10][Cl:11]>C(O)C>[ClH:11].[ClH:5].[CH3:6][N:7]([CH3:12])[CH2:8][CH2:9][CH2:10][S:3][C:2](=[NH:4])[NH2:1]

Participants

4

Reactant 2

HCID 943083-(Dimethylamino)propyl chloride hydrochlorideHCID 2723790Thiourea

Product 1

HCID 90045Dimaprit hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Equimolar quantities of thiourea and 3-(dimethylamino)-1-chloropropane hydrochloride and a little ethanol are heated together at 140° for 3 hours, and the cooled mixture is recrystallised from methanol/isopropanol to give the title product.

Workup

  1. customthe cooled mixture is recrystallised from methanol/isopropanol

Sources & evidence

ORD record
ord-9062996cf30a4f2d8df7903bf697b00e
Source dataset
uspto-grants-1978_11
Patent number
US04126670

Reaction notes

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