反应详情

A solution of 44.4 g (0.296 mol) of ethyl malonyl chloride in 80 ml of tetrahydrofuran and a solution of 29.6 g (0.296 mol) of potassium bicarbonate in 100 ml of water were added simultaneously over a 45 minute interval to a solution of 43.2 g (0.296 mol) of dithiocarbazic acid potassium salt in 200 ml of tetrahydrofuran and 200 ml of water at 5°. The reaction mixture was stirred at 5° for 1 hour then at ambient temperature for 12 hours. The solvents were evaporated and the residue was taken up into 350 ml of ethanol and refluxed on a steam bath for 1.5 hours. The mixture was evaporated to dryness, 300 ml of ethyl acetate and 175 ml of water were added to the residue and it was acidified to pH 2.3 by addition of 3N hydrochloric acid. The layers were separated and the aqueous phase was extracted twice more with 250 ml portions of ethyl acetate. The combined organic extracts were dried (MgSO4), then the solvent was evaporated to give a residue which was dissolved in methylene chloride. The methylene chloride solution was filtered and the filtrate was evaporated to dryness. The residue was chromatographed on silica gel with 98:2:3 chloroform-ethanol-formic acid as eluant to give 2-carbethoxymethyl-1,3,4-oxadiazole-5-thiol as a viscous oil.

1. waitat ambient temperature for 12 hours
2. customThe solvents were evaporated
3. temperaturerefluxed on a steam bath for 1.5 hours
4. customThe mixture was evaporated to dryness, 300 ml of ethyl acetate and 175 ml of water
5. additionwere added to the residue and it
6. additionwas acidified to pH 2.3 by addition of 3N hydrochloric acid
7. customThe layers were separated
8. extractionthe aqueous phase was extracted twice more with 250 ml portions of ethyl acetate
9. dry with materialThe combined organic extracts were dried (MgSO4)
10. customthe solvent was evaporated
11. customto give a residue which
12. filtrationThe methylene chloride solution was filtered
13. customthe filtrate was evaporated to dryness
14. customThe residue was chromatographed on silica gel with 98:2:3 chloroform-ethanol-formic acid as eluant