反应详情

To a stirred solution of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide, 3.8 parts of N,N-diethylethanamine in 200 parts of benzene are added portionwise 5 parts of 3-bromo-1-propene. After the addition is complete, the whole is heated for 21 hours at a temperature between 50°-60° C. The reaction mixture is cooled and filtered. The filtrate is washed successively with water, sodium hydrogen carbonate solution and water, dried over potassium carbonate and evaporated. The oily residue is converted into the hydrochloride salt in 1,1'-oxybisethane and 2-propanone, yielding 4 parts of N-(4-chlorophenyl)-N-[1-(2-propenyl)-4-piperidinyl]benzeneacetamide hydrochloride; mp. 225.5° C.

1. additionAfter the addition
2. temperaturethe whole is heated for 21 hours at a temperature between 50°-60° C
3. temperatureThe reaction mixture is cooled
4. filtrationfiltered
5. washThe filtrate is washed successively with water, sodium hydrogen carbonate solution and water
6. dry with materialdried over potassium carbonate
7. customevaporated