Phenacyl bromide → HCID 22758595, compound

HRID 1704713Notes

Reaction equation

HRID 1704713 reaction equation
[CH2:1](Br)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].[CH3:11][N:12]1[CH2:17][NH:16][C:15](=[S:18])[NH:14][CH2:13]1>CC(C)=O>[OH:3][C:2]1([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[N:16]2[CH2:17][N:12]([CH3:11])[CH2:13][N:14]=[C:15]2[S:18][CH2:1]1

Participants

4

Reactant 2

HCID 6259Phenacyl bromideHCID 2525988Triazinthion

Product 1

HCID 22758595HCID 22758595, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution of 5.0 grams (0.025 moles) of phenacylbromide in 40 milliliters of acetone was mixed with a solution of 3.27 grams (0.025 moles) of 3,4,5,6-tetrahydro-5-methyl-s-triazin 2(1H)thione in 450 milliliters of acetone. 6-Hydroxy-3-methyl-6-phenyl-3,4,6,7-tetrahydro-2H-thiazolo[3,2-a]-s-triazine hydrobromide crystallized out as a colourless solid, m.p. 149°-150° C. (decomposition). The yield was 7.35 grams (89%).

Workup

  1. custom6-Hydroxy-3-methyl-6-phenyl-3,4,6,7-tetrahydro-2H-thiazolo[3,2-a]-s-triazine hydrobromide crystallized out as a colourless solid, m.p. 149°-150° C. (decomposition)

Sources & evidence

ORD record
ord-a227c3926c0f4155a5e23f19aaf0f9e9
Source dataset
uspto-grants-1978_11
Patent number
US04127660

Reaction notes

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