Sodium Hydroxide → HCID 22758639, compound

HRID 1704730Notes

Reaction equation

HRID 1704730 reaction equation
O[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH3:13])=[O:12])[CH2:6][CH2:5]1.S(Cl)([Cl:22])=O.[OH-].[Na+]>C(Cl)Cl>[Cl:22][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH3:13])=[O:12])[CH2:6][CH2:5]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24386Thionyl ChlorideHCID 22758627HCID 22758627, compound

Product 1

HCID 22758639HCID 22758639, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To 1-(N-β-hydroxyethyl-piperazino)-1-phenylacetone (1 mole) dissolved in methylene chloride (2 liters) is added thionyl chloride (2 moles) dropwise, at 0° C., with stirring. On completion of the addition, the resulting material is left aside 24 hours, at room temperature. The reaction medium is then poured over ice and sodium hydroxide (3 moles) is added thereto. The organic phase is washed with water to neutral pH. It is then dried over sodium sulfate and the solvent is evaporated off, to give a viscous brown oil which is used crude to proceed with the synthesis.

Workup

  1. additionOn completion of the addition
  2. additionis added
  3. washThe organic phase is washed with water to neutral pH
  4. dry with materialIt is then dried over sodium sulfate
  5. customthe solvent is evaporated off
  6. customto give a viscous brown oil which
  7. customto proceed with the synthesis

Sources & evidence

ORD record
ord-76abc302475f48299bcd8d9c8acddc1e
Source dataset
uspto-grants-1978_11
Patent number
US04127661

Reaction notes

Loading…