Sodium Hydroxide → HCID 22758639, compound

Participants

Reaction Conditions

Reaction Steps

To 1-(N-β-hydroxyethyl-piperazino)-1-phenylacetone (1 mole) dissolved in methylene chloride (2 liters) is added thionyl chloride (2 moles) dropwise, at 0° C., with stirring. On completion of the addition, the resulting material is left aside 24 hours, at room temperature. The reaction medium is then poured over ice and sodium hydroxide (3 moles) is added thereto. The organic phase is washed with water to neutral pH. It is then dried over sodium sulfate and the solvent is evaporated off, to give a viscous brown oil which is used crude to proceed with the synthesis.

Provenance & Evidence