2-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl- → HCID 3050036, compound

HRID 1704731Notes

Reaction equation

HRID 1704731 reaction equation
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([CH3:19])=[O:18])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][N:13]([CH:16]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:17]([OH:18])[CH3:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 30500342-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl-

Product 1

HCID 3050036HCID 3050036, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

To 1-(N-2-phenoxy-ethyl-piperazino)-1-phenylacetone (1 mole) dissolved in anhydrous methanol (1 liter) is added BH4K (1 mole) portionwise, at 0° C., with stirring. On completion of the addition (1 hour), the reaction mixture is stirred 24 hours at room temperature. The methanol is removed in vacuo over a water-bath, the resulting material is then taken up into methylene chloride which is washed with water to neutral pH. Concentration gives white crystals which melt at 100° C.

Workup

  1. additionis added BH4K (1 mole) portionwise
  2. additionOn completion of the addition (1 hour)
  3. stirringthe reaction mixture is stirred 24 hours at room temperature
  4. customThe methanol is removed in vacuo over a water-bath
  5. washis washed with water to neutral pH
  6. concentrationConcentration
  7. customgives white crystals which
  8. custommelt at 100° C.

Sources & evidence

ORD record
ord-268962db1cb4492fb5cf2efe65386f95
Source dataset
uspto-grants-1978_11
Patent number
US04127661

Reaction notes

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