2-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl- → HCID 3050036, compound

Participants

Reaction Conditions

Reaction Steps

To 1-(N-2-phenoxy-ethyl-piperazino)-1-phenylacetone (1 mole) dissolved in anhydrous methanol (1 liter) is added BH4K (1 mole) portionwise, at 0° C., with stirring. On completion of the addition (1 hour), the reaction mixture is stirred 24 hours at room temperature. The methanol is removed in vacuo over a water-bath, the resulting material is then taken up into methylene chloride which is washed with water to neutral pH. Concentration gives white crystals which melt at 100° C.

Provenance & Evidence