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Piperazine → 1-(3-(Phenylthio)propyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | 3-Chloropropyl phenyl sulfide | HCID 269606 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 1-(3-(Phenylthio)propyl)piperazine | HCID 2195492 | — |
反応手順
To 1000 ml methyl ethyl ketone are added 3-phenylthio-1-chloro-propane (1 mole), sodium iodide (1 mole) and anhydrous piperazine (4 moles). The resulting mixture is refluxed during 24 hours, with stirring, after which the solvent is evaporated in vacuo, the residue is taken up into water and ether. The ether phase is washed with water, dried and concentrated. The residue is distilled in vacuo. B.p. = 140° C./0.05 mm Hg. N.M.R.: consistent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04127661 |
| 出典データセット | uspto-grants-1978_11 |
| ORD ID | ord-426cb50abb674604b9d6be065a78c485 |
| 出典メモ | uspto-grants-1978_11 |