反应详情

To 1000 ml methyl ethyl ketone are added 3-phenylthio-1-chloro-propane (1 mole), sodium iodide (1 mole) and anhydrous piperazine (4 moles). The resulting mixture is refluxed during 24 hours, with stirring, after which the solvent is evaporated in vacuo, the residue is taken up into water and ether. The ether phase is washed with water, dried and concentrated. The residue is distilled in vacuo. B.p. = 140° C./0.05 mm Hg. N.M.R.: consistent.

1. temperatureThe resulting mixture is refluxed during 24 hours
2. customafter which the solvent is evaporated in vacuo
3. washThe ether phase is washed with water
4. customdried
5. concentrationconcentrated
6. distillationThe residue is distilled in vacuo