N,N-Dimethyl-1,3-propanediamine → 8-ethyl-5-(4-methyl-1-piperazinyl)-8H-pyrazolo[4',3':5,6]-pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

HRID 1704765Notes

Reaction equation

HRID 1704765 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN(C)CCCN.[C:15]([N:23]1[C:27]2[N:28]=[CH:29][C:30]3[C:31](OC4C=CC=CC=4)=[N:32][C:33]4[N:34]([N:36]=[CH:37][N:38]=4)[C:35]=3[C:26]=2[CH:25]=[N:24]1)(=O)[C:16]1C=CC=CC=1>>[CH2:15]([N:23]1[C:27]2[N:28]=[CH:29][C:30]3[C:31]([N:5]4[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]4)=[N:32][C:33]4[N:34]([N:36]=[CH:37][N:38]=4)[C:35]=3[C:26]=2[CH:25]=[N:24]1)[CH3:16]

Participants

4

Reactant 3

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 531671-MethylpiperazineHCID 227585058-Benzoyl-5-phenyloxy-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 227585028-ethyl-5-(4-methyl-1-piperazinyl)-8H-pyrazolo[4',3':5,6]-pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

Procedure

By substituting 4-methylpiperazine for the 3-(dimethylamino)propylamine in the procedure of Example 1 (c), 8-ethyl-5-(4-methyl-1-piperazinyl)-8H-pyrazolo[4',3':5,6]-pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine is formed.

Sources & evidence

ORD record
ord-46b48811831f4129a6c184edcb87a040
Source dataset
uspto-grants-1978_11
Patent number
US04127655

Reaction notes

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