反应详情

50 g of 3-veratroylpropionic acid in 400 ml of chloroform and 22.7 g of 1,3-propanedithiol are treated with hydrogen chloride up to saturation while stirring. After 3 hours at room temperature, the solution is evaporated to 50 ml and diluted with ether. The resulting solution is extracted three times with 5% sodium carbonate. The basic phases are combined and made acidic with concentrated hydrochloric acid. The precipitated product is extracted with ether/methylene chloride (1:3). The organic extracts are dried and evaporated. The residue is recrystallized from ethanol, there being obtained 2-(3,4-dimethoxyphenyl)-m-dithiane-2-propionic acid of melting point 134°-135° C.

1. customthe solution is evaporated to 50 ml
2. additiondiluted with ether
3. extractionThe resulting solution is extracted three times with 5% sodium carbonate
4. extractionThe precipitated product is extracted with ether/methylene chloride (1:3)
5. customThe organic extracts are dried
6. customevaporated
7. customThe residue is recrystallized from ethanol, there