Diethyl (ethoxymethylene)malonate → HCID 22758849, compound

HRID 1704814Notes

Reaction equation

HRID 1704814 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][CH3:13])=[CH:4][N:3]=1.C(O[CH:17]=[C:18]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:19]([O:21][CH2:22][CH3:23])=[O:20])C>>[CH3:13][O:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([NH:1][CH:17]=[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 17905007HCID 17905007, compound

Product 1

HCID 22758849HCID 22758849, compound

Procedure

A mixture of 1-amino-4-methoxyisoquinoline (297 mg., 1.7 mmoles) and diethyl ethoxymethylenemalonate (370 mg., 1.7 mmoles) was plunged into an oil bath at 110° and kept there for 6 minutes. The mixture melted and then solidified. The crude product, m.p. 150°-153°, was used without purification.

Workup

  1. customwas plunged into an oil bath at 110°
  2. customThe crude product, m.p. 150°-153°, was used without purification

Sources & evidence

ORD record
ord-edbf425e8cee4229859b6c50bc2988ec
Source dataset
uspto-grants-1978_11
Patent number
US04127720

Reaction notes

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