Diphenyl Ether → HCID 22758807, compound

HRID 1704815Notes

Reaction equation

HRID 1704815 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([NH:13][CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16](OCC)=[O:17])=[N:5][CH:4]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>CCCCCC>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]2=[N:13][CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16](=[O:17])[N:5]2[CH:4]=1

Participants

4

Reactant 2

HCID 7583Diphenyl EtherHCID 22758849HCID 22758849, compound

Product 1

HCID 22758807HCID 22758807, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A mixture A mixture of diethyl 4-methoxyisoquinolylaminomethylenemalonate (460 mg., 1.33 mmoles) and diphenyl ether (4.6 ml.) was placed in an oil bath at 210°, the temperature of which, was increased to 260° during 5 minutes. Dilution of the solution with Skellysolve B caused the product (315 mgs., 79% yield), m.p. 190°-193°, to separate. Recrystallization from ethyl acetate raised the m.p. to 202°-204°.

Workup

  1. customwas placed in an oil bath at 210°
  2. temperaturethe temperature of which, was increased to 260° during 5 minutes
  3. customto separate
  4. customRecrystallization from ethyl acetate
  5. temperatureraised the m.p. to 202°-204°

Sources & evidence

ORD record
ord-43a5840e0ea74aa28ab4360d250cc263
Source dataset
uspto-grants-1978_11
Patent number
US04127720

Reaction notes

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