HCID 22758807, compound → HCID 22758829, compound

HRID 1704816Notes

Reaction equation

HRID 1704816 reaction equation
C[O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]2=[N:13][CH:14]=[C:15]([C:18]([O:20]CC)=[O:19])[C:16](=[O:17])[N:5]2[CH:4]=1>CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O>[OH:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]2=[N:13][CH:14]=[C:15]([C:18]([OH:20])=[O:19])[C:16](=[O:17])[N:5]2[CH:4]=1

Participants

3

Reactant 1

HCID 22758807HCID 22758807, compound

Product 1

HCID 22758829HCID 22758829, compound

Reagents, catalysts & solvents 1

HCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterSolvent

Procedure

A suspension of ethyl 7-methoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (240 mg., 0.83 mmole) in a mixture of acetic (4 ml.) and 37% hydrochloric (2 ml.) acids was refluxed for 2 hours. The mixture was flash evaporated to dryness, diluted with water and the precipitated solid collected and crystallized from acetic acid with charcoal treatment to give straw needles of the title acid, m.p. 273°-276°.

Workup

  1. temperaturewas refluxed for 2 hours
  2. customevaporated to dryness
  3. additiondiluted with water
  4. customthe precipitated solid collected
  5. customcrystallized from acetic acid with charcoal treatment

Sources & evidence

ORD record
ord-26ce852776e44b549aa7d81272f9b0de
Source dataset
uspto-grants-1978_11
Patent number
US04127720

Reaction notes

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