HCID 22758807, compound → HCID 22758829, compound

Participants

Reaction Steps

A suspension of ethyl 7-methoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (240 mg., 0.83 mmole) in a mixture of acetic (4 ml.) and 37% hydrochloric (2 ml.) acids was refluxed for 2 hours. The mixture was flash evaporated to dryness, diluted with water and the precipitated solid collected and crystallized from acetic acid with charcoal treatment to give straw needles of the title acid, m.p. 273°-276°.

Provenance & Evidence