Hydrogen Bromide → HCID 135721824, compound

HRID 1704826Notes

Reaction equation

C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13]C)[C:9]1=[N:15][CH:16]=[C:17]([C:20]([O:22]CC)=[O:21])[C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2.Br>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[C:9]1=[N:15][CH:16]=[C:17]([C:20]([OH:22])=[O:21])[C:18](=[O:19])[N:8]1[CH2:7][CH2:6]2

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 22758809HCID 22758809, compound

Product 1

HCID 135721824HCID 135721824, compoundYield 82%

Procedure

Ethyl 6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate was treated with 48% hydrogen bromide as described in Example 19 to give a 82% yield of the title acid, m.p. 308°-314°. Recrystallization from N,N-dimethylformamide gave the analytical sample, m.p. 321°-323°.

Sources & evidence

ORD record: ord-77bc778b356e46be8b29461a6a5bfef8
Source dataset: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04127720

Reaction notes

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