Acetone → 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde

HRID 170568Notes

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([Cl:21])[c:5]([NH:8][c:9]2[c:10]([CH2:19][OH:20])[cH:11][c:12]3[c:13]([n:14][cH:15][nH:16]3)[c:17]2[F:18])[cH:6][cH:7]1.[CH3:22][C:23]([CH3:24])=[O:25].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[O:31]=[Mn:32]=[O:33]>>[Br:1][c:2]1[cH:3][c:4]([Cl:21])[c:5]([NH:8][c:9]2[c:10]([CH:19]=[O:20])[cH:11][c:12]3[c:13]([n:14][cH:15][nH:16]3)[c:17]2[F:18])[cH:6][cH:7]1

Participants

Reactant 4

HCID 180Acetone

HCID 8028Tetrahydrofuran

HCID 14801Manganese dioxide

HCID 11428680[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-methanol

Product 1

HCID 112456086-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazole-5-carbaldehyde

Sources & evidence

ORD record: ord-b833c90182da42d3b9da63280e6e576e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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