Acetic Anhydride → HCID 20337441, compound

HRID 1706257Notes

Reaction equation

HRID 1706257 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH:12]([CH3:22])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[NH:8][C:7]([CH3:24])([CH3:23])[C:6]1[CH2:25][CH2:26][CH2:27][C:28](=[O:29])[C:5]2=1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>N1C=CC=CC=1>[C:30]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH:12]([CH3:22])[CH2:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[NH:8][C:7]([CH3:23])([CH3:24])[C:6]1[CH2:25][CH2:26][CH2:27][C:28](=[O:29])[C:5]2=1)(=[O:32])[CH3:31]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20337419HCID 20337419, compound

Product 1

HCID 20337441HCID 20337441, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Pyridine (2.2 ml.) is added to a suspension of 5,6,7,8,9,10-hexahydro-2-hydroxy-3-(1-methyl-4-phenylbutyl)-6,6-dimethyl-10-oxobenzo[c]quinoline (250 mg., 0.642 mmole) in 2.2 ml. of acetic anhydride under a nitrogen atmosphere. The mixture is stirred for 1.5 hours at room temperature and then poured onto ice (50 ml.). The mixture is extracted with ether, the extracts washed with water (4×50 ml.) and brine (1×60 ml.), dried (MgSO4) and evaporated under reduced pressure.

Workup

  1. additionpoured onto ice (50 ml.)
  2. extractionThe mixture is extracted with ether
  3. washthe extracts washed with water (4×50 ml.) and brine (1×60 ml.)
  4. dry with materialdried (MgSO4)
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-fa8ed62452294589a570e3b35652e477
Source dataset
uspto-grants-1980_06
Patent number
US04206225

Reaction notes

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