反应详情

温度

5 °C

2-Chloro-3-methoxy-5-nitropyridine (1.5 g, 0.008 mole) was added to concentrated hydrochloric acid (15 ml) at 5° C., followed by stannous chloride (5.0 g). The reaction mixture was stirred for 10 minutes at 5° C., heated for 30 minutes on a steam bath, cooled, neutralized with aqueous sodium hydroxide (20 percent by weight) and extracted with 1,1,1-trichloroethane. The trichloroethane extract was dried over MgSO4 and evaporated in vacuo to yield a white solid; yield, 1.02 g (91 percent), m.p. 93° to 94° C.

1. temperatureheated for 30 minutes on a steam bath
2. temperaturecooled
3. extractionextracted with 1,1,1-trichloroethane
4. extractionThe trichloroethane extract
5. dry with materialwas dried over MgSO4
6. customevaporated in vacuo
7. customto yield a white solid
8. customyield