Ethylene Oxide → HCID 53643383, compound

HRID 1706330Notes

Reaction equation

HRID 1706330 reaction equation
[CH3:1][C:2]1([CH3:14])[CH2:8][C:7](=[O:9])[NH:6][CH:5]2[CH2:10][CH2:11][CH2:12][CH2:13][CH:4]2[NH:3]1.[CH2:15]1[O:17][CH2:16]1>C(O)C.C1C=CC=CC=1>[OH:17][CH2:16][CH2:15][N:3]1[CH:4]2[CH2:13][CH2:12][CH2:11][CH2:10][CH:5]2[NH:6][C:7](=[O:9])[CH2:8][C:2]1([CH3:14])[CH3:1]

Participants

5

Reactant 2

HCID 6354Ethylene OxideHCID 20334758HCID 20334758, compound

Product 1

HCID 53643383HCID 53643383, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 702EthanolSolvent

Procedure

38.6 g 4,4-dimethyl-decahydro-1,5-benzodiazepin-2-one is placed in a 250 ml flask with a slight molar excess of ethylene oxide (about 13.2 g) dissolved in ethyl alcohol. The reaction is run in an autoclave at 170°-180° C. A viscous brown paste is obtained which is dissolved in benzene. Upon recrystallization from benzene a white solid is obtained having a melting pt. 154°-156° C.

Workup

  1. customis run in an autoclave at 170°-180° C
  2. customA viscous brown paste is obtained which
  3. customUpon recrystallization from benzene a white solid
  4. customis obtained

Sources & evidence

ORD record
ord-34a2b63497b544558149dce601e7c567
Source dataset
uspto-grants-1980_06
Patent number
US04207228

Reaction notes

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