反应详情

The solution of 4.7 g of 1-phenyl-3-methyl-2-pyrazolin-5-one in 75 ml of benzene and 3.3 g of triethylamine is combined with the solution of 5.1 g of 2,5-dichlorophenylisocyanate in 25 ml of benzene. After warming the mixture briefly on the steam cone, the resulting solution is allowed to stand for 2 hours at room temperature. It is evaporated, the residue triturated with diethyl ether and recrystallized from methanol-diethyl ether to yield the triethylammonium salt-methanolate of the 1-phenyl-3-methyl-4-(2,5-dichlorophenylcarbamoyl)-2-pyrazolin-5-one, melting at 142°-147°, resolidifying and remelting at 154°-159°.

1. temperatureAfter warming the mixture briefly on the steam cone
2. customIt is evaporated
3. customthe residue triturated with diethyl ether
4. customrecrystallized from methanol-diethyl ether