Ammonium Hydroxide → 1,2-Diethyl-4-pyrazolidinamine

A mixture of 100 g. (0.615 mole) of 4-chloro-1,2-diethylpyrazolidine and 200 ml. of concentrated ammonium hydroxide in a closed steel chamber was heated at 150° C. for approximately 36 hours. The cooled reaction mixture was extracted with isopropyl ether, the aqueous layer saturated with potassium carbonate and continuously extracted with chloroform for six hours. The dried chloroform extract (sodium sulfate) was concentrated at reduced pressure and the residue distilled at 113°-115° C./40 mm. to give 40.5 g. (45.5%) of product.

1. additionA mixture of 100 g
2. customThe cooled reaction mixture
3. extractionwas extracted with isopropyl ether
4. extractionthe aqueous layer saturated with potassium carbonate and continuously extracted with chloroform for six hours
5. extractionThe dried chloroform extract (sodium sulfate)
6. concentrationwas concentrated at reduced pressure
7. distillationthe residue distilled at 113°-115° C./40 mm
8. customto give 40.5 g

ORD record

ord-8f2a4e9863b0401ab2a22d6a422b98fb

Source dataset

uspto-grants-1980_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04207327