反应详情

150 grams of 2-benzoyl-3-nitro-6-mercaptopyridine were dissolved in a solution of 45 grams of sodium hydroxide in 2.5 liters of water and hereto there was added dropwise at 35° C. with stirring 90 ml. of dimethyl sulfate. Then the composition was stirred for one hour at 40° C. After cooling the precipitated crystals were filtered off with suction and recrystallized from 1.8 liters of methanol.

1. additionwas added dropwise at 35° C.
2. stirringThen the composition was stirred for one hour at 40° C
3. temperatureAfter cooling the precipitated crystals
4. filtrationwere filtered off with suction
5. customrecrystallized from 1.8 liters of methanol