Dimethylamine → HCID 20336081, compound

HRID 1706500Notes

Reaction equation

[C:1]1([CH:7](Br)[CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][NH:23][CH3:24]>>[CH3:22][N:23]([CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)[CH3:24]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 20336054HCID 20336054, compound

Product 1

HCID 20336081HCID 20336081, compound

Procedure

Still following the above procedure, 1-phenyl-3-(p-trifluoromethylphenoxy)propylbromide was reacted with dimethylamine in a sealed vessel at 150° C. for a period of 8 hours. N,N-dimethyl 1-phenyl-3-(p-trifluoromethylphenoxy)-propylamine thus formed was converted to the hydrochloride salt by the addition to the reaction mixture of 100 ml. of 10% aqueous HCl. The hydrochloride salt was isolated therefrom and melted at 178°-180° C. after recrystallization from an ethyl acetate-hexane solvent mixture.

Sources & evidence

ORD record: ord-d224b7f298ee4cc0aa784ba02baf9479
Source dataset: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04207343

Reaction notes

Loading…