Dimethylamine → HCID 20336081, compound

Participants

Reaction Steps

Still following the above procedure, 1-phenyl-3-(p-trifluoromethylphenoxy)propylbromide was reacted with dimethylamine in a sealed vessel at 150° C. for a period of 8 hours. N,N-dimethyl 1-phenyl-3-(p-trifluoromethylphenoxy)-propylamine thus formed was converted to the hydrochloride salt by the addition to the reaction mixture of 100 ml. of 10% aqueous HCl. The hydrochloride salt was isolated therefrom and melted at 178°-180° C. after recrystallization from an ethyl acetate-hexane solvent mixture.

Provenance & Evidence