反应详情

A solution of 12.4 g (0.10 moles) of 3-hydroxy-3-methylglutaronitrile in 107 ml of 1.3 M sodium hydroxide is stirred at room temperature while 17.4 ml (0.20 moles) of 30% hydrogen peroxide is slowly added. After the addition of peroxide, the mixture is heated to boiling and boiling is maintained for 2 hours. Thereafter the mixture is cooled, diluted to 1 liter with water and passed through a 200 ml column of Dowex 2 resin in the formate form. The column is then washed with 1 liter of water. Thereafter the product is eluted with 1 liter of 0.1 N formic acid and the eluate evaporated to dryness to afford 3-hydroxy-3-methylglutaric acid monoamide.

1. additionis slowly added
2. temperaturethe mixture is heated
3. temperatureboiling is maintained for 2 hours
4. temperatureThereafter the mixture is cooled
5. washThe column is then washed with 1 liter of water
6. washThereafter the product is eluted with 1 liter of 0.1 N formic acid
7. customthe eluate evaporated to dryness