3-Hydroxy-3-methylglutaric acid monoamide methyl ester → 3-Hydroxy-3-methylglutaric acid monoamide

HRID 1706595Notes

Reaction equation

HRID 1706595 reaction equation
C[O:2][C:3](=[O:12])[CH2:4][C:5]([OH:11])([CH3:10])[CH2:6][C:7]([NH2:9])=[O:8]>[OH-].[Na+].O>[OH:11][C:5]([CH3:10])([CH2:4][C:3]([OH:12])=[O:2])[CH2:6][C:7]([NH2:9])=[O:8]

Participants

4

Reactant 1

HCID 443709073-Hydroxy-3-methylglutaric acid monoamide methyl ester

Product 1

HCID 127207103-Hydroxy-3-methylglutaric acid monoamide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

1.56 g. (0.01 moles) of 3-hydroxy-3-methylglutaric acid monoamide methyl ester is dissolved in 10 ml of 1 N sodium hydroxide. After 24 hours at room temperature the solution is diluted to 50 ml with water and passed through a 50 ml column of Dowex 50 (H30 ) resin. The column is washed with 100 ml of water and the washings collected and evaporated to afford 3-hydroxy-3-methylglutaric acid monoamide.

Workup

  1. washThe column is washed with 100 ml of water
  2. customthe washings collected
  3. customevaporated

Sources & evidence

ORD record
ord-7ec5e3fb01bf4664b95d187d6887daf5
Source dataset
uspto-grants-1980_06
Patent number
US04208204

Reaction notes

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