3-Hydroxy-3-methylglutaric acid monoamide methyl ester → 3-Hydroxy-3-methylglutaric acid monoamide

Participants

Reaction Steps

1.56 g. (0.01 moles) of 3-hydroxy-3-methylglutaric acid monoamide methyl ester is dissolved in 10 ml of 1 N sodium hydroxide. After 24 hours at room temperature the solution is diluted to 50 ml with water and passed through a 50 ml column of Dowex 50 (H30 ) resin. The column is washed with 100 ml of water and the washings collected and evaporated to afford 3-hydroxy-3-methylglutaric acid monoamide.

Provenance & Evidence