反应详情

To a solution of 12 g methyl benzilate and 8.2 g 1-benzyl-3-pyrrolidinol in 200 ml n-heptane is added 100 mg sodium hydride and the mixture refluxed for 4 hours, separating the methanol formed in a Dean-Stark separator. The cooled organic phase is washed with water and then extracted with 2N HCl. The aqueous phase is made alkaline with solid K2CO3 and extracted with ether to give 1-benzyl-3-(2,2-diphenyl-2-hydroxyacetoxy)pyrrolidine as an oil (18.2 g).

1. temperaturethe mixture refluxed for 4 hours
2. customseparating the methanol
3. customformed in a Dean-Stark separator
4. washThe cooled organic phase is washed with water
5. extractionextracted with 2N HCl
6. extractionextracted with ether