反应详情

13.8 g. of 2,5-dimethyl resorcinol were dissolved in a mixed solution comprising 70 ml of isopropyl ether and 5 ml of concentrated sulfuric acid. Then, 10 g. of 4-methyl-3-pentene-2-ol were added dropwise to the solution at the temperature of about 60° C. for about 30 minutes. The resulting solution was cooled, and washed with water, with 1 N sodium hydroxide solution, and again with water and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure. The residue was recrystallized from ether/n-hexane, to obtain 13.2 g. (yield: 60%) of the subject compound. Melting point: 88°-89° C.

1. temperatureThe resulting solution was cooled
2. washwashed with water, with 1 N sodium hydroxide solution
3. dry with materialagain with water and then dried over magnesium sulfate
4. distillationThe solvent was distilled off under reduced pressure
5. customThe residue was recrystallized from ether/n-hexane
6. customto obtain 13.2 g