反应详情

A mixture of 0.28 g. of 3'-(3-trifluoromethylphenyl)-spiro[isobenzofuran-1(3H), 5'(4'H)-isoxazol]-3-one, 0.5 ml. of concentrated HCl, 10 ml. of water and 6 ml. of dioxane was stirred at reflux for one hour. The mixture was cooled and filtered to give 0.25 g. of white solid; m.p. 176.5°-178° C. in 89% yield.

1. additionA mixture of 0.28 g
2. temperatureat reflux for one hour
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. customto give 0.25 g