2-Methyl-2-thiopseudourea sulfate → 58579-77-4

HRID 1706787Notes

Reaction equation

HRID 1706787 reaction equation
C(O[C:4](=[O:16])[CH2:5][NH:6][CH2:7][C:8]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:15])C.S(O)(O)(=O)=O.CS[C:24](=N)[NH2:25]>C(O)C>[CH3:14][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:8]=1[CH2:7][N:6]1[CH2:5][C:4](=[O:16])[NH:25][C:24]1=[N:15]2

Participants

4

Reactant 2

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 12204071HCID 12204071, compound

Product 1

HCID 13544933658579-77-4Yield 10.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-(2-amino-6-methylbenzyl)glycine ethyl ester (0.972 g, 0.00437 mole) and 2-methyl-2-thiopseudourea sulfate (0.609 g, 0.00219 mole) in absolute ethanol (15 ml) was stirred at reflux for 16 hours. Workup as in Example 2 gave the title compound (47 mg), identical (ir) with authentic material prepared according to the procedure of J. Med. Chem., 18, 224 (1975).

Workup

  1. temperatureat reflux for 16 hours

Sources & evidence

ORD record
ord-ec075479741b4ffa8c0b0f1969286900
Source dataset
uspto-grants-1980_06
Patent number
US04208521

Reaction notes

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