Piperonal → 1-(3,4-Methylenedioxyphenyl)-4-morpholino-1-butene-3-one

HRID 1706866Notes

Reaction equation

HRID 1706866 reaction equation
[CH:1]1[C:6]([CH:7]=O)=[CH:5][C:4]2[O:9][CH2:10][O:11][C:3]=2[CH:2]=1.[O:12]1[CH2:17][CH2:16][N:15]([CH2:18][C:19](=[O:21])[CH3:20])[CH2:14][CH2:13]1>[OH-].[Na+]>[CH2:10]1[O:11][C:3]2[CH:2]=[CH:1][C:6]([CH:7]=[CH:20][C:19](=[O:21])[CH2:18][N:15]3[CH2:16][CH2:17][O:12][CH2:13][CH2:14]3)=[CH:5][C:4]=2[O:9]1

Participants

4

Reactant 2

HCID 8438PiperonalHCID 110299481-(4-Morpholinyl)acetone

Product 1

HCID 479671-(3,4-Methylenedioxyphenyl)-4-morpholino-1-butene-3-one

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

15 g of piperonal (0.1 mole), and 14.3 g of 3-morpholinoacetone (0.1 mole) are mixed in an aqueous-alcoholic sodium hydroxide solution (300 cm3 of 10% NaOH and 30 cm3 of ethanol). The mixture is stirred for 4 hours and the product obtained is then filtered. The product is rinsed with water and recrystallised from ethanol.

Workup

  1. customthe product obtained
  2. filtrationis then filtered
  3. washThe product is rinsed with water
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-a6230ee247bb4822ab01e7931917fcdd
Source dataset
uspto-grants-1980_06
Patent number
US04209517

Reaction notes

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