Formaldehyde → HCID 3050515, compound

HRID 1706869Notes

Reaction equation

HRID 1706869 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]=[CH:11][C:12](=[O:15])[CH2:13][CH3:14])=[CH:4][C:3]=2[O:2]1.[CH2:16]=O.Cl.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10]=[CH:11][C:12](=[O:15])[CH:13]([CH3:16])[CH2:14][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[CH:4][C:3]=2[O:2]1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 66316HCID 66316, compoundHCID 197884Morpholine, hydrochloride (1:1)

Product 1

HCID 3050515HCID 3050515, compound

Procedure

A mixture of 20 g of 1-(3,4-methylenedioxyphenyl)-1-pentene-3-one (0.1 mole), 3 g of paraformaldehyde (0.1 mole) and 12.2 g of morpholine hydrochloride (0.1 mole) in 100 cm3 of absolute alcohol adjusted to a pH of 3 is refluxed for 9 hours. The alcohol is removed and the product is taken up in water. The product is then extracted with chloroform, and the basic, aqueous phase is taken and re-extracted with benzene. A yellow oil is obtained which can be used for the reduction of Example 6.

Workup

  1. temperatureis refluxed for 9 hours
  2. customThe alcohol is removed
  3. extractionThe product is then extracted with chloroform
  4. extractionre-extracted with benzene
  5. customA yellow oil is obtained which

Sources & evidence

ORD record
ord-194f81171ad14d4fa4699a566575f080
Source dataset
uspto-grants-1980_06
Patent number
US04209517

Reaction notes

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