Thionyl Chloride → HCID 20332916, compound

HRID 1706871Notes

Reaction equation

HRID 1706871 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1.CC1OC(C)O[CH:11]([CH3:16])O1.S(Cl)([Cl:19])=O>C1C=CC=CC=1>[Cl:19][CH:11]([N:3]1[C:2](=[O:1])[CH:6]=[C:5]([CH3:7])[O:4]1)[CH3:16]

Participants

5

Reactant 3

HCID 24386Thionyl ChlorideHCID 24781HymexazolHCID 31264Paraldehyde

Product 1

HCID 20332916HCID 20332916, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 2.97 g of 3-hydroxy-5-methylisoxazole, 1.32 g of paraldehyde, 3 ml of thionyl chloride and 20 ml of benzene was stirred for 1 hour at 40°-50° C. On evaporating off the solvent and excess thionyl chloride, there were obtained 4.97 g of crude, crystalline 2-(1-chloroethyl)-5-methyl-4-isoxazolin-3-one.

Workup

  1. customOn evaporating off the solvent and excess thionyl chloride

Sources & evidence

ORD record
ord-6c68c42aa06b4d60a7dff0115b60159b
Source dataset
uspto-grants-1980_06
Patent number
US04209512

Reaction notes

Loading…