Sodium Hydroxide → HCID 20333078, compound

HRID 1706926Notes

Reaction equation

HRID 1706926 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([NH:17][C:18]([NH:20]C(=O)C3C=CC=CC=3)=[O:19])[CH2:13][CH2:12]2)=[CH:2]1.[OH-].[Na+]>O.CO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][N:11]2[CH2:12][CH2:13][CH:14]([NH:17][C:18]([NH2:20])=[O:19])[CH2:15][CH2:16]2)=[CH:2]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 175174Wy 25093

Product 1

HCID 20333078HCID 20333078, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

1-[1-(Indol-3-ylmethyl)piperid-4-yl]-3-benzoylurea (0.5 g, 1.33 mmol) was added to a solution of sodium hydroxide (1 g, 0.025 mol) in water (4 ml) and methanol (16 ml). The resulting suspension was stirred for 3 hours until all the solid material had dissolved then allowed to stand at room temperature overnight, giving a blue solution. The solvents were evaporated in vacuo and the solid residue triturated thoroughly with water, collected and dried (0.32 g, 88.9%). The obtained title compound was then recrystallised from aqueous ethanol, mp--softens slowly from 122°-128° C.

Workup

  1. dissolutionhad dissolved
  2. waitto stand at room temperature overnight
  3. customgiving a blue solution
  4. customThe solvents were evaporated in vacuo
  5. customthe solid residue triturated thoroughly with water
  6. customcollected
  7. customdried (0.32 g, 88.9%)

Sources & evidence

ORD record
ord-bbf0a62505744bb78b8086d643a6db26
Source dataset
uspto-grants-1980_06
Patent number
US04209521

Reaction notes

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