Sodium Hydroxide → HCID 20333078, compound

Participants

Reaction Steps

1-[1-(Indol-3-ylmethyl)piperid-4-yl]-3-benzoylurea (0.5 g, 1.33 mmol) was added to a solution of sodium hydroxide (1 g, 0.025 mol) in water (4 ml) and methanol (16 ml). The resulting suspension was stirred for 3 hours until all the solid material had dissolved then allowed to stand at room temperature overnight, giving a blue solution. The solvents were evaporated in vacuo and the solid residue triturated thoroughly with water, collected and dried (0.32 g, 88.9%). The obtained title compound was then recrystallised from aqueous ethanol, mp--softens slowly from 122°-128° C.

Provenance & Evidence