Benzyl Bromide → HCID 10317544, compound

HRID 1706939Notes

Reaction equation

HRID 1706939 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([Cl:16])[C:13]([Cl:15])=[CH:14][C:9]=2[NH:8][C:7]1=[O:17])[CH3:2].[CH2:19](Br)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([Cl:16])[C:13]([Cl:15])=[CH:14][C:9]=2[N:8]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:7]1=[O:17])[CH3:2]

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 10108207HCID 10108207, compound

Product 1

HCID 10317544HCID 10317544, compound

Procedure

The procedure described in Example 1 was repeated (using the same molar proportions as before) except that 210 mg. (0.0007 mole) of 5,6-dichloro-2-oxo-1-benzimidazolineacetic acid ethyl ester (prepared according to the procedure described in Preparation A) and 120 mg. (0.0007 mole) of benzyl bromide were reacted to afford crude 3-benzyl-5,6-dichloro-2-oxo-1-benzimidazolineacetic acid ethyl ester, which was used as such in the next reaction step (viz., hydrolysis to the corresponding acid as hereinafter described in Example 24) without any further purification being necessary.

Workup

  1. customdescribed in Preparation A) and 120 mg

Sources & evidence

ORD record
ord-e0baa28a48584e8a87b3a7f3705dee67
Source dataset
uspto-grants-1980_06
Patent number
US04209527

Reaction notes

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