Pyridine → 2-Hydrazino-5-phenylpyrimidine

HRID 1707044Notes

Reaction equation

HRID 1707044 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1.N1C=CC=CC=1.O.[NH2:21][NH2:22]>O>[NH:21]([C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1)[NH2:22]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24654Hydrazine hydrate (1:1)HCID 6053202-Chloro-5-phenylpyrimidine

Product 1

HCID 141699362-Hydrazino-5-phenylpyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 5.4 g. of 2-chloro-5-phenylpyrimidine in 25 ml. of pyridine is added 25 ml. of hydrazine hydrate. The mixture is heated on a steam bath for one hour with occasional swirling. Water is added and the material that is separated is collected and crystallized from methanol to give 4.5 g. of the product of the Example, m.p. 155° C.

Workup

  1. temperatureThe mixture is heated on a steam bath for one hour
  2. customthe material that is separated
  3. customis collected
  4. customcrystallized from methanol
  5. customto give 4.5 g

Sources & evidence

ORD record
ord-0dedac35560640c38892fcf397a01082
Source dataset
uspto-grants-1980_06
Patent number
US04209621

Reaction notes

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